| Primary Identifier | MGI:96788 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 16880 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). PHENOTYPE: Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
