| Primary Identifier | MGI:95314 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 109901 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables serine-type endopeptidase activity. Acts upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Located in collagen-containing extracellular matrix. Is expressed in alveolus epithelium; lung; pancreas; pancreas tip epithelium; and right lung accessory lobe. Orthologous to human CELA1 (chymotrypsin like elastase 1). PHENOTYPE: Mice homozygous for a null allele exhibit reduced elastase activity in distal airspace walls, increased elastin fibers in airspace walls, increased wet-to-dry lung weight ratio, and increased lung elastance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
