Primary Identifier | MGI:2686922 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 239743 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6). PHENOTYPE: Mice homozygous for a knock-out allele exhibit spleen hypoplasia, defects in mature B-cell subsets with normal pro- and pre-B-cell development, severely impaired antigen-dependent germinal center formation, and reduced memory IgG response. [provided by MGI curators] |