Primary Identifier | MGI:2443815 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 207227 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within glucose homeostasis; negative regulation of insulin secretion; and regulation of exocytosis. Is active in neuromuscular junction and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; brain; male reproductive gland or organ; spinal cord; and trigeminal nerve. Orthologous to human STXBP5L (syntaxin binding protein 5L). PHENOTYPE: Mice homozygous for a knock-out allele exhibit background sensitive embryonic/postnatal lethality, altered motor performance and impaired NMJ neurotransmission. [provided by MGI curators] |