Primary Identifier | MGI:1196990 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 17470 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Involved in negative regulation of cell population proliferation; negative regulation of macrophage activation; and negative regulation of neuroinflammatory response. Located in cell surface. Is active in postsynaptic density and presynaptic active zone. Is expressed in several structures, including anterior naris; bone; metanephros; nervous system; and retina. Used to study autoimmune disease. Orthologous to human CD200 (CD200 molecule). PHENOTYPE: Mice homozygous for disruptions in this gene have increased levels of all macrophage lineages. Macrophage are activated and mice display an increased susceptibility to autoimmune disease. [provided by MGI curators] |