Primary Identifier | MGI:104754 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 17691 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including cAMP response element binding protein binding activity; enzyme binding activity; and ion binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and negative regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). PHENOTYPE: Mice homozygous for a knock-out allele and fed a high fat diet exhibit increased insulin sensitivity. [provided by MGI curators] |