| Primary Identifier | MGI:2146785 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 106512 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable GTPase regulator activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response; positive regulation of inflammatory response; and positive regulation of leukocyte chemotaxis. Located in plasma membrane. Is expressed in genitourinary system; gut; skin; and thymus. Orthologous to human GPSM3 (G protein signaling modulator 3). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit a reduction in the number, viability, and chemotactic function of monocytes and show decreased susceptibility to collagen antibody-induced arthritis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
