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Protein Coding Gene : Safb scaffold attachment factor B

Primary Identifier  MGI:2146974 Organism  Mus musculus
Chromosome  17 NCBI Gene Number  224903
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.2)

Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including hormone metabolic process; intracellular estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleoplasm. Is expressed in several structures, including central nervous system; future brain; olfactory epithelium; reproductive system; and retina layer. Orthologous to human SAFB (scaffold attachment factor B).
PHENOTYPE: Homozygous null mice display partial embryonic and neonatal lethality, neonatal cyanosis, impaired embryonic hematopoiesis, male sterility, azoospermia, reduced female fertility, impaired transport of embryos through the oviduct, reduced embryonic growth, testicular degeneration and ovarian atrophy. [provided by MGI curators]
  • synonyms:
  • MGI:2147152,
  • 5330423C17Rik,
  • RIKEN cDNA 3110021E02 gene,
  • expressed sequence D18386,
  • MGI:1920397,
  • Safb,
  • scaffold attachment factor B,
  • SAFB1,
  • MGI:1925522,
  • 3110021E02Rik,
  • RIKEN cDNA 5330423C17 gene,
  • D18386,
  • AU018122,
  • expressed sequence AU018122

Features --> Cross References


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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


5 Pathways

74 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles


Mouse features --> Human diseases


Mouse features --> Publications