| Primary Identifier | MGI:2150380 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 94224 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Acts upstream of or within androgen biosynthetic process and male genitalia development. Predicted to be located in cell body fiber and neuronal cell body. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). PHENOTYPE: Homozygous null mutant males are fertile, but have small prostates and seminal vesicles, elevated testosterone in reproductive tissue and decreased androgen-dependent gene expression. Mutant females exhibit no detectable abnormality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
