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Protein Coding Gene : Nrxn1 neurexin I

Primary Identifier  MGI:1096391 Organism  Mus musculus
Chromosome  17 NCBI Gene Number  18189
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources

Exhibits several functions, including calcium channel regulator activity; calcium-dependent protein binding activity; and signaling receptor binding activity. Involved in several processes, including nervous system development; postsynaptic membrane organization; and regulation of synapse organization. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; axonal growth cone; and integral component of presynaptic active zone membrane. Predicted to colocalize with the slit diaphragm. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Is expressed in several structures, including limb; nervous system; neural retina; nose; and oral epithelium. Orthologous to human NRXN1 (neurexin 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+). [provided by MGI curators]
  • synonyms:
  • alpha-latrotoxin receptor (calcium-dependent),
  • MGI:1915292,
  • 9330127H16Rik,
  • neurexin I,
  • MGI:2442437,
  • 1700062G21Rik,
  • Nrxn1,
  • RIKEN cDNA A230068P09 gene,
  • A230068P09Rik,
  • RIKEN cDNA 9330127H16 gene,
  • MGI:2444963,
  • mKIAA0578,
  • neurexin I alpha,
  • neurexin I beta,
  • RIKEN cDNA 1700062G21 gene

Features --> Cross References


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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


3 Pathways

907 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles


Mouse features --> Human diseases


Mouse features --> Publications