| Primary Identifier | MGI:1914776 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 67526 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to contribute to Atg8-family ligase activity. Involved in autophagosome assembly; negative regulation of defense response; and negative regulation of type I interferon production. Located in phagophore assembly site membrane. Part of Atg12-Atg5-Atg16 complex. Is expressed in central nervous system; dorsal root ganglion; heart; lower jaw molar; and retina. Orthologous to human ATG12 (autophagy related 12). PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality. Mice homozygous for a conditional allele activated in POMC neurons exhibit increased diet-induced obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
