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Protein Coding Gene : Pstpip2 proline-serine-threonine phosphatase-interacting protein 2
Primary Identifier  MGI:1335088 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  19201
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Located in cytoskeleton; cytosol; and membrane. Used to study chronic recurrent multifocal osteomyelitis. Orthologous to human PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2).
PHENOTYPE: Homozygous mutant animals develop osteomyelitis (bone inflammation). Tail kinks are observed starting at 6-8 weeks of age and chronic inflammation of the extremities and ears is subsequently seen. Extramedullary hematopoiesis in the spleen is observed. [provided by MGI curators]
  • synonyms:
  • chronic multifocal osteomyelitis,
  • MGD-MRK-2028,
  • cmo,
  • Pstpip2,
  • MGI:88427,
  • proline-serine-threonine phosphatase-interacting protein 2
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