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Protein Coding Gene : Abl1 c-abl oncogene 1, non-receptor tyrosine kinase

Primary Identifier  MGI:87859 Organism  Mus musculus
Chromosome  2 NCBI Gene Number  11350
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Localizes to several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute myeloid leukemia; and chronic myeloid leukemia. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase).
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis. [provided by MGI curators]
  • synonyms:
  • AI325092,
  • c-Abl,
  • MGD-MRK-1015,
  • MGI:2138905,
  • Abl1,
  • MGI:2443781,
  • expressed sequence AI325092,
  • E430008G22Rik,
  • c-abl oncogene 1, non-receptor tyrosine kinase,
  • RIKEN cDNA E430008G22 gene

Features --> Cross References


Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

13 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


23 Pathways

366 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles


Mouse features --> Human diseases


Mouse features --> Publications