| Primary Identifier | MGI:1861100 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 68795 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables ubiquitin protein ligase activity. Involved in embryo development; sensory perception of smell; and ubiquitin-dependent protein catabolic process. Acts upstream of or within in utero embryonic development; olfactory behavior; and suckling behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion and dorsal root ganglion. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
