Primary Identifier | MGI:1913126 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 229615 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables SUMO transferase activity. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; negative regulation of osteoclast differentiation; and protein sumoylation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; central nervous system; eye; genitourinary system; and maxillary process. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). PHENOTYPE: Double KO mice display a retinal phenotype reduced M-cone response at P21 and reduced S-cone and rod responses from 7 months. [provided by MGI curators] |