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Protein Coding Gene : Nras neuroblastoma ras oncogene

Primary Identifier  MGI:97376 Organism  Mus musculus
Chromosome  3 NCBI Gene Number  18176
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Localizes to membrane. Is expressed in several structures, including central nervous system; early embryo; eye; heart; and metanephros. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); epidermal nevus; and hematologic cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase).
PHENOTYPE: Mice homozygous for a targeted mutation are viable and fertile with no gross morphological or histological abnormalities, or defects in peripheral blood cell populations. Mice homozygous for an LTR insertion in intron 1 exhibit weight loss immune defectsand postnatal lethality. [provided by MGI curators]
  • synonyms:
  • AV095280,
  • expressed sequence AV095280,
  • N-ras,
  • MGI:2139934,
  • neuroblastoma ras oncogene,
  • Nras,
  • MGD-MRK-12932

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

81 Pathways

545 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications