| Primary Identifier | MGI:1914256 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 67006 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within autophagy. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Is expressed in central nervous system and retina. Used to study Wolfram syndrome 2. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2). PHENOTYPE: Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
