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Protein Coding Gene : Acot11 acyl-CoA thioesterase 11
Primary Identifier  MGI:1913736 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  329910
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis and response to cold. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol. Orthologous to human ACOT11 (acyl-CoA thioesterase 11).
PHENOTYPE: Mice homozygous for a null mutation display resistance to high fat diet induced obesity, inflammation and hepatic steatosis, increased energy expenditure, increased brown adipose tissue amount, and increased food intake. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1110020M10 gene,
  • thioesterase, adipose associated,
  • mKIAA0707,
  • expressed sequence AW060409,
  • MGI:2140551,
  • RIKEN cDNA 2010309H15 gene,
  • MGC:25974,
  • MGI:1915900,
  • 2010309H15Rik,
  • Acot11,
  • Thea,
  • BFIT1,
  • Them1,
  • AW060409,
  • 1110020M10Rik,
  • acyl-CoA thioesterase 11
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4 Involved In Mutations

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Disease

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