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Protein Coding Gene : Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor

Primary Identifier  MGI:1194912 Organism  Mus musculus
Chromosome  4 NCBI Gene Number  19646
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-dependent ATPase activity. Predicted to be involved in DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; and chromatin remodeling. Localizes to ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina nuclear layer. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor).
PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. Cultured blastocysts fail to form typical outgrowth colonies. [provided by MGI curators]
  • synonyms:
  • retinoblastoma binding protein 4, chromatin remodeling factor,
  • Rbbp4,
  • RBAP48,
  • CAF-1 p48 subunit

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

32 Pathways

382 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications