| Primary Identifier | MGI:97367 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230899 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable hormone receptor binding activity; neuropeptide hormone activity; and neuropeptide receptor binding activity. Involved in female pregnancy and regulation of blood pressure. Acts upstream of or within cardiac muscle hypertrophy in response to stress; negative regulation of blood pressure; and sodium ion export across plasma membrane. Located in cytoplasm and extracellular space. Is expressed in several structures, including heart and skeletal muscle. Used to study hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); congestive heart failure; heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). PHENOTYPE: Homozygotes are chronically hypertensive partly due to changes in peripheral resistance and increased central AT1-receptor activation, and show salt-sensitive hypertension and abnormal pulmonary vascular remodeling with increased ventricular mass and muscularization of peripheral pulmonary vessels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
