| Primary Identifier | MGI:2151156 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 116873 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable calcium channel regulator activity; calcium ion binding activity; and store-operated calcium channel activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcium ion transport; and store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; endocrine gland; and male reproductive gland or organ. Orthologous to human STIM2 (stromal interaction molecule 2). PHENOTYPE: Mice homozygous for a null allele exhibit a slight growth delay and premature death while embryonic fibroblasts show reduced store-operated Ca2+ influx. Mice homozygous for a different null allele show increased neuron survival under hypoxic conditions and resistance to ischemic brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
