Primary Identifier | MGI:1918168 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 70918 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable RNA binding activity and S-adenosylmethionine-dependent methyltransferase activity. Acts upstream of or within flagellated sperm motility and sperm mitochondrion organization. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; neural ectoderm; and sensory organ. Orthologous to human NSUN7 (NOP2/Sun RNA methyltransferase family member 7). PHENOTYPE: Males homozygous for an ENU-induced mutation are either infertile or subfertile. Mutant sperm exhibit poor progressive motility linked to rigidity of the flagellar midpiece and abnormal electron density patterns in the mitochondrial sheath. [provided by MGI curators] |