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Protein Coding Gene : Pcgf3 polycomb group ring finger 3
Primary Identifier  MGI:1916837 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  69587
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables histone H2AK119 ubiquitin ligase activity. Involved in random inactivation of X chromosome. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit limb defects and spleen agenesis. [provided by MGI curators]
  • synonyms:
  • polycomb group ring finger 3,
  • expressed sequence AI662857,
  • Pcgf3,
  • AI662857,
  • DONG1,
  • ring finger protein 3,
  • 2310035N15Rik,
  • RNF3A,
  • Rnf3,
  • D630042K08Rik,
  • RIKEN cDNA D630042K08 gene,
  • RIKEN cDNA 2310035N15 gene,
  • MGI:2445213,
  • MGI:2140956
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