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Protein Coding Gene : Tchp trichoplein, keratin filament binding

Primary Identifier  MGI:1925082 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  77832
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Predicted to act upstream of or within cell projection organization. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding).
PHENOTYPE: Mice homozygous for a null allele are resistant to high-fat diet-induced obesity and show abnormal adipogenesis with adipogenic progenitor cells showing elongated cilia and impaired adipocyte differentiation. [provided by MGI curators]
  • synonyms:
  • A930031F18Rik,
  • Tchp,
  • MGI:2141121,
  • expressed sequence AV279199,
  • AV279199,
  • trichoplein, keratin filament binding,
  • RIKEN cDNA A930031F18 gene

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Genome

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2 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Mouse features --> Functions (GO terms)

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