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Protein Coding Gene : Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit

Primary Identifier  MGI:107940 Organism  Mus musculus
Chromosome  6 NCBI Gene Number  14056
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to ESC/E(Z) complex; chromatin silencing complex; and pronucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
PHENOTYPE: Homozygous null mutants die prior to completing gastrulation. A conditional mutant with loss of expression in immune cells survives, but has defects in early B cell development and Igh rearrangement. Conditional loss of maternal protein results in severegrowth retardation of neonates. Conditional loss in oligodendrocytes affects oligodendrocyte maturation and delays subsequent myelinization of axons in the central nervous system by oligodendrocytes. [provided by MGI curators]
  • synonyms:
  • MGI:106670,
  • MGD-MRK-36520,
  • KMT6,
  • Enx1h,
  • Enx-1,
  • enhancer of zeste 2 polycomb repressive complex 2 subunit,
  • MGD-MRK-35129,
  • Ezh2,
  • enhancer of zeste homolog (Drosophila)

Features --> Cross References


Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


18 Pathways

220 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles


Mouse features --> Human diseases


Mouse features --> Publications