Primary Identifier | MGI:2442232 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 317757 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of biosynthetic process; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in endosome; lysosome; and membrane. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to several human genes including GIMAP5 (GTPase, IMAP family member 5). PHENOTYPE: Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis. [provided by MGI curators] |