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Protein Coding Gene : Setd5 SET domain containing 5

Primary Identifier  MGI:1920145 Organism  Mus musculus
Chromosome  6 NCBI Gene Number  72895
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits histone methyltransferase activity (H3-K36 specific) and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including histone H3-K36 trimethylation; regulation of DNA-templated transcription, elongation; and regulation of synapse assembly. Localizes to nuclear euchromatin. Colocalizes with Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 23. Orthologous to human SETD5 (SET domain containing 5).
PHENOTYPE: Homozygous inactivation of this gene causes embryonic or fetal lethality. Observed phenotypes include embryonic growth retardation, impaired neural tube formation, somitogenesis and cardiac development, abnormal vasculogenesis in embryos, yolk sacs and placentas, hemorrhage and increased apoptosis. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2900045N06 gene,
  • expressed sequence C85544,
  • SET domain containing 5,
  • Setd5,
  • C85544,
  • mKIAA1757,
  • 2900045N06Rik,
  • MGI:2141772

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

684 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications