| Primary Identifier | MGI:1196250 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 27007 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of natural killer cell mediated cytotoxicity. Acts upstream of or within several processes, including positive regulation of biosynthetic process; response to bacterium; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in tropical spastic paraparesis. Orthologous to several human genes including KLRK1 (killer cell lectin like receptor K1). PHENOTYPE: Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
