| Primary Identifier | MGI:2676630 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 378425 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein-macromolecule adaptor activity. Involved in negative regulation of inflammatory response and negative regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within cellular response to cytokine stimulus; dendritic cell migration; and negative regulation of ERK1 and ERK2 cascade. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). PHENOTYPE: Mice homozygous for a null allele have defects in dendritic and myeloid cell migration and a decreased susceptibility to type IV hypersensitivity reactions. Mice homozygous for a second null allele display increased susceptibility to induced colitis and to chemically-induced tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
