Primary Identifier | MGI:2386851 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233046 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of Ras protein signal transduction; and response to extracellular stimulus. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; liver; peritoneal cavity; spleen; and tongue. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil reactive oxygen species production and chemotaxis in vitro. Mice homozygous for another knock-out allele exhibit decreased susceptibility to induced colitis and arthritis. [provided by MGI curators] |