Primary Identifier | MGI:1342299 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 20174 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Part of ribonucleoprotein complex. Is expressed in several structures, including axial musculature; branchial arch; embryo mesenchyme; sensory organ; and viscerocranium. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit lethality. Mice heterozygous for a knock-out allele exhibit impaired T cell development and maximal T dependent antibody responses. [provided by MGI curators] |