| Primary Identifier | MGI:1913335 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66085 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). PHENOTYPE: Mice homozygous for a knock-out allele exhibit early embryonic lethality. Heterozygotes show partial prenatal lethality, reduced lean body mass, decreased skeletal muscle mass and fiber size, and increased susceptibility to induced muscular atrophy associated with reduced protein synthesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
