| Primary Identifier | MGI:1923739 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 233877 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables identical protein binding activity. Involved in negative regulation of Rho protein signal transduction and positive regulation of synaptic transmission. Predicted to be located in nuclear body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human KCTD13 (potassium channel tetramerization domain containing 13). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced synaptic transmission, abnormal hippocampal pyramidal neuron dendrite morphology, and hyperactivity. Another null allele shows reduced male fertility and increased incidence of cryptorchidism and micropenis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
