Primary Identifier | MGI:2142048 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 233900 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including enzyme binding activity; protein homodimerization activity; and syntaxin-1 binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of macromolecule metabolic process and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and islets of Langerhans. Orthologous to human RNF40 (ring finger protein 40). PHENOTYPE: Colon-specific knock-out results in decreased susceptibility to induced colitis and increased bone strength. [provided by MGI curators] |