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Protein Coding Gene : Hras Harvey rat sarcoma virus oncogene

Primary Identifier  MGI:96224 Organism  Mus musculus
Chromosome  7 NCBI Gene Number  15461
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Exhibits GTP binding activity. Involved in several processes, including T cell receptor signaling pathway; defense response to protozoan; and intracellular signal transduction. Predicted to localize to several cellular components, including Golgi apparatus; glutamatergic synapse; and nucleoplasm. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; astrocytoma; and malignant glioma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
PHENOTYPE: Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated. [provided by MGI curators]
  • synonyms:
  • H-ras,
  • Hras1,
  • MGD-MRK-10931,
  • Ha-ras,
  • Harvey rat sarcoma virus oncogene,
  • Harvey-ras,
  • MGD-MRK-10930,
  • Harvey rat sarcoma virus oncogene 1,
  • c-rasHa,
  • Hras-1,
  • c-H-ras,
  • Hras

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

16 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

82 Pathways

212 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications