| Primary Identifier | MGI:96920 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17173 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and bHLH transcription factor binding activity. Involved in several processes, including T follicular helper cell differentiation; negative regulation of T-helper cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; and spongiotrophoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculoskeletal system. Orthologous to human ASCL2 (achaete-scute family bHLH transcription factor 2). PHENOTYPE: Mice homozygous for a knock-out allele or heterozygous for a maternally inherited allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
