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Protein Coding Gene : Gab1 growth factor receptor bound protein 2-associated protein 1

Primary Identifier  MGI:108088 Organism  Mus musculus
Chromosome  8 NCBI Gene Number  14388
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Involved in several processes, including activation of JUN kinase activity; cell surface receptor signaling pathway; and labyrinthine layer development. Localizes to cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1).
PHENOTYPE: Homozygotes for targeted null mutations exhibit developmental defects in the placenta, heart, eye, muscle, and skin, and die between embryonic day 13.5 and 18.5. [provided by MGI curators]
  • synonyms:
  • MGI:2142758,
  • expressed sequence AA408973,
  • expressed sequence AW107238,
  • growth factor receptor bound protein 2-associated protein 1,
  • AA408973,
  • MGD-MRK-37125,
  • Gab1,
  • AW107238,
  • MGI:2142409

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

45 Pathways

414 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications