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Protein Coding Gene : Gins3 GINS complex subunit 3
Primary Identifier  MGI:1926083 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  78833
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to be involved in DNA unwinding involved in DNA replication and mitotic DNA replication initiation. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human GINS3 (GINS complex subunit 3).
PHENOTYPE: Homozygous deletion is embryonic lethal. Homozygosity for a hypomorphic point mutation affects DNA replication and cellular senescence and leads to pre-weaning lethality. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2700085M18 gene,
  • MGI:2142596,
  • expressed sequence AI616142,
  • Gins3,
  • 2700085M18Rik,
  • Psf3,
  • AI616142,
  • GINS complex subunit 3
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