Primary Identifier | MGI:1917976 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 70726 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable signaling receptor binding activity. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in secretory granule. Is expressed in brain. Used to study obesity. Orthologous to human ANGPTL6 (angiopoietin like 6). PHENOTYPE: Most mice homozygous for a knock-out allele die around E13 with cardiovascular defects; survivors develop obesity, lipid accumulation in skeletal muscle and liver, hyperglycemia and hyperinsulinemia, and insulin resistance accompanied by reduced energy expenditure and whole-body oxygen consumption. [provided by MGI curators] |