| Primary Identifier | MGI:1923759 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 76509 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in negative regulation of cell-matrix adhesion; positive regulation of cell migration; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and external side of plasma membrane. Is expressed in several structures, including branchial arch; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human PLET1 (placenta expressed transcript 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased gut permeability, impaired tissue repair of DSS-induced damage in colon epithelium, and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
