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Protein Coding Gene : Gfral GDNF family receptor alpha like

Primary Identifier  MGI:3607786 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  404194
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and response to metformin. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like).
PHENOTYPE: Homozygous knockout leads to increased susceptibility to diet-induced obesity caused by overeating and reduced glucose tolerance. [provided by MGI curators]
  • synonyms:
  • AY457637,
  • GDNF family receptor alpha like,
  • cDNA sequence AY457637,
  • Gfral,
  • GRAL-A,
  • GRAL,
  • GRAL-B

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

4 Driver For