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Protein Coding Gene : Me1 malic enzyme 1, NADP(+)-dependent, cytosolic

Primary Identifier  MGI:97043 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  17436
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; nicotinamide nucleotide metabolic process; and protein homotetramerization. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human ME1 (malic enzyme 1).
PHENOTYPE: Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet. [provided by MGI curators]
  • synonyms:
  • malic enzyme, supernatant,
  • MGI:1098755,
  • MGD-MRK-12345,
  • MGD-MRK-12341,
  • Mod1,
  • D9Ertd267e,
  • malic enzyme 1, NADP(+)-dependent, cytosolic,
  • MGD-MRK-12164,
  • Mod-1,
  • DNA segment, Chr 9, ERATO Doi 267, expressed,
  • Me1,
  • Mdh-1

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For