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Protein Coding Gene : Pcbp4 poly(rC) binding protein 4

Primary Identifier  MGI:1890471 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  59092
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and negative regulation of mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; lung; metanephros; and sensory organ. Orthologous to human PCBP4 (poly(rC) binding protein 4).
PHENOTYPE: Mice homozygous or heterozygous for a knock-out allele are reduced in body weight and prone to lung adenocarcinoma, B cell derived lymphoma and lung tumors. [provided by MGI curators]
  • synonyms:
  • MGI:1914112,
  • AlphaCP-4,
  • RIKEN cDNA 1200003L19 gene,
  • poly(rC) binding protein 4,
  • 1200003L19Rik,
  • Pcbp4

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Canonical gene --> Transcripts in specific strains.

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