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Protein Coding Gene : Ubb ubiquitin B

Primary Identifier  MGI:98888 Organism  Mus musculus
Chromosome  11 NCBI Gene Number  22187
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Predicted to have protein tag and ubiquitin protein ligase binding activity. Involved in animal organ development; energy homeostasis; and meiosis I. Localizes to myelin sheath. Is expressed in oocyte. Orthologous to human UBB (ubiquitin B).
PHENOTYPE: Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-15326,
  • ubiquitin 2,
  • ubiquitin B,
  • MGD-MRK-33606,
  • expressed sequence AL033289,
  • MGI:2141542,
  • Ubb2,
  • AL033289,
  • Ubb

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

4 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

280 Pathways

72 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications