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Protein Coding Gene : St6galnac1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Primary Identifier  MGI:1341826 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  20445
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1).
PHENOTYPE: A specific missense mutation affects protein glycosylation in intestinal endothelial cells and leads to thinning of the colon inner mucus layer, increased microbial invasion of colon mucus and more severe DSS-induced colitis. [provided by MGI curators]
  • synonyms:
  • ST6GalNAc I,
  • Siat7a,
  • sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A,
  • sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase A,
  • St6galnac1,
  • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
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