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Protein Coding Gene : Ang angiogenin, ribonuclease, RNase A family, 5
Primary Identifier  MGI:88022 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  11727
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables tRNA-specific ribonuclease activity. Involved in defense response to other organism; response to yeast; and tRNA destabilization. Located in growth cone and neuronal cell body. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and respiratory system. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin).
PHENOTYPE: Knock-out mice show increased proliferative capacity of hematopoietic stem/progenitor cells and decreased proliferative capacity of myeloid-restricted progenitor cells and develop leukopenia. [provided by MGI curators]
  • synonyms:
  • AI385586,
  • Rnase5a,
  • angiogenin, ribonuclease, RNase A family, 5,
  • expressed sequence AI385586,
  • Ang1,
  • Ang,
  • MGD-MRK-1320,
  • angiogenin, ribonuclease A family, member 1,
  • MGI:2145626
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Features --> Cross References

Genome

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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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