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Publication : Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.

First Author  Pangas SA Year  2006
Journal  Proc Natl Acad Sci U S A Volume  103
Issue  21 Pages  8090-5
PubMed ID  16690745 Mgi Jnum  J:110210
Mgi Id  MGI:3639633 Doi  10.1073/pnas.0601083103
Citation  Pangas SA, et al. (2006) Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A 103(21):8090-5
abstractText  Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary homeobox gene (Nobox) and factor in the germ-line alpha (Figla). In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis.
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