| First Author | Driessen CA | Year | 1997 |
| Journal | Gene | Volume | 203 |
| Issue | 1 | Pages | 27-31 |
| PubMed ID | 9426003 | Mgi Jnum | J:44704 |
| Mgi Id | MGI:1101218 | Doi | 10.1016/s0378-1119(97)00486-1 |
| Citation | Driessen CA, et al. (1997) Cloning and structural analysis of the murine GCN5L1 gene. Gene 203(1):27-31 |
| abstractText | We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776 nt. The murine GCNSL1 gene consists of four exons encompassing approximately 3.5 kb of genomic DNA. Intron/exon splice sites conform to the GT/AG rule. The open reading frame consists of 375 nucleotides encoding a 14 kDa protein. The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved. |
