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Comment :

Type  disruption phenotype Description  Knockouts show reduced viability with reduced growth and a shortened skull (PubMed:30973865). Mutants show increased thresholds across all frequencies associated with variable amounts of accumulated fluid and exudate containing inflammatory cells in the middle ear, suggesting predisposition to otitis media. The middle ear mucosa appear thickened with granulation tissue in sections and the luminal surface show an open Eustachian tube but abundant clusters of goblet cells with fewer ciliated epithelial cells (PubMed:30973865).