| First Author | Pearce EL | Year | 2003 |
| Journal | Science | Volume | 302 |
| Issue | 5647 | Pages | 1041-3 |
| PubMed ID | 14605368 | Mgi Jnum | J:154842 |
| Mgi Id | MGI:4399030 | Doi | 10.1126/science.1090148 |
| Citation | Pearce EL, et al. (2003) Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 302(5647):1041-3 |
| abstractText | Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity. |
